Associations between Human Aldosterone Synthase (CYP11B2) and Angiotensin II type 1 Receptor (ATR1) Gene Polymorphisms with End Stage Renal Disease In hypertensive Egyptian Patients on Maintenance Hemodialysis

摘要: Many people with an advanced form of kidney disease do not know they have weak or failing kidneys, but early detection and treatment can help prevent the progression to failure. The resulting costs ESRD are enormous. is a complex phenotype, which results from presence underlying disease, superimposing inherited environmental factors. Among predisposing genetic factors, renin-angiotensin-aldosterone system (RAAS) disruption clearly involved in development. aim this study evaluate association between CYP11B 2 C-344T ATR 1 A1166C gene polymorphisms increased risk for hypertensive Egyptian patients on maintenance hemodialysis. This included 70 hemodialysis (32 males 28 females, mean age 54.5± 9.5 years, recruited El Doaah Rayan hospitals, Cairo, Egypt. healthy individuals, matching sex (30 40 50.2 ± 13.1 years), were also study. All subjects genotyped both CYP11B2 ATR1 polymorphisms. Serum aldosterone was measured all subjects. Concerning gene, HD showed frequency TT genotype (68.57%) as compared controls (only 12.85%), no significant differences T allele distribution groups. In contrast, had low CC (5.71%) (32.85%), difference C (28.56%) (70.7%). Comparing serum levels various genotypes revealed that statistically higher (121.583 43.311) than those TC (72.055 11.709) (68.75 13.145). On other hand, AT1R frequency, significantly (p˂0.05) (70%) (7.1%), lower AA (57%). Moreover, there A (27.13%) (64.25%).  same true allele, (59.28%) (39.25%) controls. studying (121.25 43.006) (87.6 25.4) genotype.