Passive immunotherapeutic strategies for the treatment of malignant gliomas.
作者： Daniel T. Nagasawa , Christina Fong , Andrew Yew , Marko Spasic , Heather M. Garcia
DOI: 10.1016/J.NEC.2012.04.008
关键词: Cell therapy 、 Antibody 、 Normal tissue 、 Passive Immunotherapy 、 Medicine 、 Pathology 、 Tumor tissue 、 Toxicity 、 Intracranial tumor 、 Parenchyma
摘要: Malignant gliomas are the most common primary intracranial tumor, with a proclivity for widespread invasion and rampant destruction of healthy parenchyma. This infiltrative process affords high-grade protection from traditional therapies subjects adjacent normal tissue to potential damage nonspecific treatment modalities.1,2 Immunotherapies involving antibodies or sensitized effector cells can offer selective targeting protein-arbohydrate complexes on tumor cell surfaces that distinguish neoplastic noncancerous cells.1,3 Consequently, malignant may be enhanced not only by increased specificity but also decreased toxicity host’s cells.1 review focuses published findings use passive immunotherapy gliomas, particularly glioblastoma multiforme (GBM).
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