Lipid-lowering effect of artichoke on liver phosphatidate phosphohydrolase and plasma lipids in hyperlipidemic rats
作者： Effat. Jafari-Dehkordi , Esfandiar. Heidarian , Ali. Seidkhani-Nahal
DOI: 10.5897/JMPR.9000852
关键词: Biochemistry 、 Oxidative stress 、 Malondialdehyde 、 Endocrinology 、 Ethanol 、 High-density lipoprotein 、 Internal medicine 、 Hyperlipidemia 、 Sunflower oil 、 Chemistry 、 Cholesterol 、 Antioxidant
摘要: Artichoke ( Cynara scolymus L.) is full of natural antioxidants and has a lipid-lowering effect. The aim this study was to investigate the effect artichoke on liver phosphatidate phosphohydrolase (PAP), plasma lipid levels, malondialdehyde (MDA), antioxidant in hyperlipidemic rats. Male rats were fed by standard pellet diet (Group 1), supplemented with 10% 2), lipogenic (containing sunflower oil, cholesterol ethanol) plus 3) only 4). On day 60 experiment, PAP activity, triglyceride (TG), lipids, MDA, levels measured. TG, ratio total (TC) high density lipoprotein (HDL) cholesterol, TC TG significantly decreased due treatment Groups 2 3 compared 1 4, respectively. Significant reduction MDA significant elevation power observed results clearly indicated that can be useful for activity TG. Also, beneficial effects controlling hyperlipidemia, abnormalities profiles oxidative stress regimes.
sci-hub.st 参考文章(40)
James M. McKenney, Pharmacotherapy of dyslipidemia. Cardiovascular Drugs and Therapy. ,vol. 15, pp. 413- 422 ,(2001) , 10.1023/A:1013341606476
I N Fleming, S J Yeaman, Purification and characterization of N-ethylmaleimide-insensitive phosphatidic acid phosphohydrolase (PAP2) from rat liver Biochemical Journal. ,vol. 308, pp. 983- 989 ,(1995) , 10.1042/BJ3080983
Barbara Wider, Max H Pittler, Joanna Thompson-Coon, Edzard Ernst, Artichoke leaf extract for treating hypercholesterolaemia Cochrane Database of Systematic Reviews. ,vol. 2002, pp. 003335- ,(2016) , 10.1002/14651858.CD003335.PUB3
WilliamH Frishman, Biologic markers as predictors of cardiovascular disease The American Journal of Medicine. ,vol. 104, ,(1998) , 10.1016/S0002-9343(98)00184-3
Rolf Gebhardt, Inhibition of Cholesterol Biosynthesis in Primary Cultured Rat Hepatocytes by Artichoke (Cynara scolymus L.) Extracts Journal of Pharmacology and Experimental Therapeutics. ,vol. 286, pp. 1122- 1128 ,(1998)
Mingfu Wang, James E Simon, Irma Fabiola Aviles, Kan He, Qun-Yi Zheng, Yaakov Tadmor, None, Analysis of antioxidative phenolic compounds in artichoke (Cynara scolymus L.) Journal of Agricultural and Food Chemistry. ,vol. 51, pp. 601- 608 ,(2003) , 10.1021/JF020792B
Erin E. Mulvihill, Murray W. Huff, Antiatherogenic properties of flavonoids: Implications for cardiovascular health Canadian Journal of Cardiology. ,vol. 26, pp. 17- ,(2010) , 10.1016/S0828-282X(10)71056-4
Kitt Falk Petersen, Gerald I. Shulman, Etiology of Insulin Resistance The American Journal of Medicine. ,vol. 119, pp. 10- 16 ,(2006) , 10.1016/J.AMJMED.2006.01.009
Hiroshi Ohkawa, Nobuko Ohishi, Kunio Yagi, Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Analytical Biochemistry. ,vol. 95, pp. 351- 358 ,(1979) , 10.1016/0003-2697(79)90738-3
V. Sudhahar, S. Ashok Kumar, P. Varalakshmi, R. Sundarapandiyan, Mitigating role of lupeol and lupeol linoleate on hepatic lipemic-oxidative injury and lipoprotein peroxidation in experimental hypercholesterolemia Molecular and Cellular Biochemistry. ,vol. 295, pp. 189- 198 ,(2007) , 10.1007/S11010-006-9288-2