Stimulation of the periaqueductal gray matter inhibits nociception at the supraspinal as well as spinal level.
作者： Michael M. Morgan , Jin-Hun Sohn , John C. Liebeskind
DOI: 10.1016/0006-8993(89)90461-7
关键词: Periaqueductal gray 、 Nociception 、 Hot plate test 、 Central nervous system 、 Stimulation 、 Spinal cord 、 Tail flick test 、 Internal medicine 、 Lesion 、 Medicine 、 Endocrinology 、 Neuroscience
摘要: Stimulation of the periaqueductal gray matter (PAG) is known to modulate nociception at spinal level. Several studies have suggested that may also be modulated via ascending projections from PAG. To study this hypothesis, descending pathway was selectively disrupted immediately caudal PAG in 28 rats. Twenty-eight additional rats served as non-lesioned controls. All animals were chronically implanted with a stimulating electrode PAG, and antinociception assessed using tests involving spinally supraspinally mediated responses (tail-flick hot-plate tests, respectively). Significantly fewer lesioned than showed stimulation-produced analgesia (SPA) tail-flick test (4 vs 14 28, In contrast, no significant difference incidence SPA occurred between test. These findings demonstrate can supraspinal, well spinal,
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sci-hub.se 参考文章(33)
GAYLORD D. ELLISON, The Use of Microknives in Brain Lesion Studies and the Production of Isolated Brain-stem Islands Methods in Psychobiology#R##N#Specialized Laboratory Techniques in Neuropsychology and Neurobiology. pp. 303- 318 ,(1972) , 10.1016/B978-0-12-512302-0.50015-8
LD Aimone, GF Gebhart, Stimulation-produced spinal inhibition from the midbrain in the rat is mediated by an excitatory amino acid neurotransmitter in the medial medulla. The Journal of Neuroscience. ,vol. 6, pp. 1803- 1813 ,(1986) , 10.1523/JNEUROSCI.06-06-01803.1986
Allan I. Basbaum, Nicholas J.E. Marley, John OʼKeefe, Charles H. Clanton, Reversal of morphine and stimulus-produced analgesia by subtotal spinal cord lesions. Pain. ,vol. 3, pp. 43- 56 ,(1977) , 10.1016/0304-3959(77)90034-3
Paul J. Camarata, Tony L. Yaksh, Characterization of the spinal adrenergic receptors mediating the spinal effects produced by the microinjection of morphine into the periaqueductal gray. Brain Research. ,vol. 336, pp. 133- 142 ,(1985) , 10.1016/0006-8993(85)90424-X
Horacio Vanegas, Nicholas M. Barbaro, Howard L. Fields, Midbrain stimulation inhibits tail-flick only at currents sufficient to excite rostral medullary neurons Brain Research. ,vol. 321, pp. 127- 133 ,(1984) , 10.1016/0006-8993(84)90688-7
A. Herz, M.H. Millan, M.J. Millan, Depletion of central β-endorphin blocks midbrain stimulation produced analgesia in the freely-moving rat Neuroscience. ,vol. 18, pp. 641- 649 ,(1986) , 10.1016/0306-4522(86)90059-X
G.J. Prieto, J.T. Cannon, J.C. Liebeskind, N. raphe magnus lesions disrupt stimulation-produced analgesia from ventral but not dorsal midbrain areas in the rat Brain Research. ,vol. 261, pp. 53- 57 ,(1983) , 10.1016/0006-8993(83)91282-9
Eve Andersen, Nachum Dafny, An ascending serotonergic pain modulation pathway from the dorsal raphe nucleus to the parafascicularis nucleus of the thalamus Brain Research. ,vol. 269, pp. 57- 67 ,(1983) , 10.1016/0006-8993(83)90962-9
Herbert K. Proudfit, Reversible inactivation of raphe magnus neurons: effects on nociceptive threshold and morphine-induced analgesia Brain Research. ,vol. 201, pp. 459- 464 ,(1980) , 10.1016/0006-8993(80)91053-7
J.T. Cannon, G.J. Prieto, A. Lee, J.C. Liebeskind, Evidence for opioid and non-opioid forms of stimulation-produced analgesia in the rat. Brain Research. ,vol. 243, pp. 315- 321 ,(1982) , 10.1016/0006-8993(82)90255-4