Survival in multiple system atrophy: a study of prognostic factors in 59 cases.
作者： D. Testa , G. Filippini , M. Farinotti , E. Palazzini , T. Caraceni
DOI: 10.1007/BF00868999
关键词: Olivopontocerebellar atrophy 、 Surgery 、 Internal medicine 、 Striatonigral Degeneration 、 Disease 、 Central nervous system disease 、 Neuroradiology 、 Neurology 、 Medicine 、 Atrophy 、 Degenerative disease
摘要: The various clinical features of multiple system atrophy (MSA) make the diagnosis disease difficult, especially in its early stages, when signs differentiated neuroanatomical involvement have not yet appeared. Mortality studies may be affected by variability diagnostic criteria and selection bias. We used strict MRI to diagnose MSA 59 patients. Patients with parkinsonian cerebellar onset were compared. Median survival time from first motor symptom was 7.5 years. Our results indicated a trend (P = 0.09) for Northwestern University Disability Scale score correlate mortality, but we failed find other characteristics identifying subgroups or predictors survival.
springer.com
elsevier.com
sci-hub.se 参考文章(20)
A.E. Harding, "Idiopathic" late onset cerebellar ataxia. A clinical and genetic study of 36 cases. Journal of the Neurological Sciences. ,vol. 51, pp. 259- 271 ,(1981) , 10.1016/0022-510X(81)90104-0
T Klockgether, G Schroth, H C Diener, J Dichgans, Idiopathic cerebellar ataxia of late onset: natural history and MRI morphology. Journal of Neurology, Neurosurgery, and Psychiatry. ,vol. 53, pp. 297- 305 ,(1990) , 10.1136/JNNP.53.4.297
Wenning G, Quinn N, MULTIPLE SYSTEM ATROPHY British Journal of Hospital Medicine. ,vol. 51, pp. 492- 494 ,(1994)
M Savoiardo, L Strada, F Girotti, R A Zimmerman, M Grisoli, D Testa, R Petrillo, Olivopontocerebellar atrophy: MR diagnosis and relationship to multisystem atrophy. Radiology. ,vol. 174, pp. 693- 696 ,(1990) , 10.1148/RADIOLOGY.174.3.2305051
J G Graham, D R Oppenheimer, Orthostatic hypotension and nicotine sensitivity in a case of multiple system atrophy. Journal of Neurology, Neurosurgery, and Psychiatry. ,vol. 32, pp. 28- 34 ,(1969) , 10.1136/JNNP.32.1.28
GERALD J. CANTER, ROLANDO de La TORRE, MANUEL MIER, A method for evaluating disability in patients with Parkinson's disease. Journal of Nervous and Mental Disease. ,vol. 133, pp. 143- 147 ,(1961) , 10.1097/00005053-196108000-00010
Daniela Perani, Sergio Bressi, Daniela Testa, Franco Grassi, Pietro Cortelli, Silvia Gentrini, Mario Savoiardo, Tommaso Caraceni, Ferruccio Fazio, Clinical/metabolic correlations in multiple system atrophy : a fludeoxyglucose F 18 positron emission tomographic study JAMA Neurology. ,vol. 52, pp. 179- 185 ,(1995) , 10.1001/ARCHNEUR.1995.00540260085021
N Quinn, Multiple system atrophy--the nature of the beast. Journal of Neurology, Neurosurgery, and Psychiatry. ,vol. 52, pp. 78- 89 ,(1989) , 10.1136/JNNP.52.SUPPL.78
J.P. Larsen, E. Dupont, E. Tandberg, Clinical diagnosis of Parkinson's disease. Proposal of diagnostic subgroups classified at different levels of confidence. Acta Neurologica Scandinavica. ,vol. 89, pp. 242- 251 ,(2009) , 10.1111/J.1600-0404.1994.TB01674.X
M. Wakai, A. Kume, A. Takahashi, T. Ando, Y. Hashizume, A study of parkinsonism in multiple system atrophy: clinical and MRI correlation. Acta Neurologica Scandinavica. ,vol. 90, pp. 225- 231 ,(2009) , 10.1111/J.1600-0404.1994.TB02712.X