Nicotinic antagonists enhance process outgrowth by rat retinal ganglion cells in culture.

摘要: Functional nicotinic cholinergic receptors are found on mammalian retinal ganglion cell neurons in culture. The neurotransmitter acetylcholine (ACh) can be detected the medium of many these cultures, after release presumably from choline acetyltransferase-positive amacrine cells. postsynaptic effect endogenous or applied ACh cells blocked with specific antagonists. Here it is shown that within 24 hours producing such a pharmacologic blockade, begin to sprout regenerate neuronal processes. Thus, growth-enhancing antagonists may due removal inhibition growth by tonic levels present culture medium. Since there spontaneous leak intact retina, effects drugs process outgrowth reflect normal control mechanism for regeneration processes exerted vivo.