Molecular epidemiology and carcinogenesis: endogenous and exogenous carcinogens.

摘要: Mutations of the p53 tumor suppressor gene are found in about 50% all human cancers. The mutation spectra these cancers providing clues to etiology and molecular pathogenesis cancer. Recent studies indicate that protein is involved several vital cellular functions, such as transcription, DNA synthesis repair, cell cycle arrest, senescence programmed death. can abrogate functions may contribute genomic instability progression Characteristic have been associated with dietary aflatoxin B(1) (AFB(1)) exposure hepatocellular carcinoma (HCC); sunlight skin cancer; cigarette smoking lung spectrum also reveals those mutants provide cells a selective clonal expansion advantage during multistep process carcinogenesis. Although number different exogenous carcinogens shown selectively target p53, pieces evidence supporting endogenous insult accumulating. Furthermore, analysis characteristic load nontumorous tissue previous carcinogen identify individuals at an increased cancer risk.