Protective effects of ascorbic acid and garlic extract against neurogenesis inhibition caused by developmental lead exposure in the dentate gyrus of rat
作者： Fatemeh Alipour , Alireza Ebrahimzaheh Bideskan , Alireza Fazel , Akram Sadeghi , Javad Hami
DOI: 10.1007/S00580-014-1895-9
关键词: Biochemistry 、 Doublecortin 、 Ascorbic acid 、 Lead acetate 、 Hippocampus 、 Internal medicine 、 Neurogenesis 、 Dentate gyrus 、 Neurotoxicity 、 Neurotoxin 、 Endocrinology 、 Biology 、 Anatomy 、 Pathology and Forensic Medicine
摘要: Lead is a well-known neurotoxin that affects the developing central nervous system and may potentially inhibit neurogenesis in adults. We investigated effect of ascorbic acid garlic extract against lead-induced neurotoxicity rat dentate gyrus. Female Wistar rats were divided randomly into five groups: lead-treated (L; 1,500 ppm lead acetate drinking water) group, plus acid-treated (L + AA; 500 mg/kg, ip) juice-treated (L + G; 1 ml /100 g BW, gavage) sham group (sh), controls. All treatments administered to female during pregnancy lactation. At end treatment, gyrus determined using Doublecortin (DCX) immunohistochemistry hippocampus 50-day-old male pups. DCX-positive cells counted compared between groups. exposure caused significant increase blood brain concentration vs. control (P < 0.001); whereas, co-administration or garlic + lead was effective reducing levels (P < 0.01). The number lead-exposed significantly lower, when with A statistically groups noted (P < 0.05). This study provides evidence beneficial role early status exposure.
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