An Efficient Synthesis of Chromeno[2,3‐d]pyrimidine‐2,4‐diones with a Nitroketene‐Aminal Moiety at C(5) by a One‐Pot Four‐Component Reaction
作者： Abdolali Alizadeh , Rashid Ghanbaripour , Seik Weng Ng
关键词: Organic chemistry 、 Barbituric acid 、 Moiety 、 Aminal 、 Pyrimidine 、 Chemistry 、 Four component 、 Combinatorial chemistry
摘要: An efficient and novel synthesis of chromeno[2,3-d]pyrimidine-2,4-dione derivatives with a nitroketene-aminal moiety at C(5) via four-component reaction salicylaldehydes, barbituric acid, diamines, 1,1-bis(methylsulfanyl)-2-nitroethene in EtOH the presence AcOH is reported. Easy performance, good yields, easy purification are main advantages this method. All structures were confirmed by IR, MS, 1H- 13C-NMR, X-ray crystal-structure analyses. A plausible mechanism for type proposed (Scheme).
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