TiO2 foams with poly-(d,l-lactic acid) (PDLLA) and PDLLA/Bioglass® coatings for bone tissue engineering scaffolds
作者： Saša Novak , John Druce , Qi-Zhi Chen , Aldo R. Boccaccini
DOI: 10.1007/S10853-008-2858-9
关键词: Materials science 、 Compressive strength 、 Scaffold 、 Coating 、 Bioactive glass 、 Lactic acid 、 Layer (electronics) 、 Composite material 、 Simulated body fluid 、 Porosity
摘要: TiO2 foam-like scaffolds with pore size ~300 μm and >95% porosity were fabricated by the foam replication method. A new approach to improve structural integrity of as-sintered foams, which exhibit extremely low compression strength, was explored coating them poly-(d,l-lactic acid) (PDLLA) or PDLLA/Bioglass® layers. The PDLLA shown mechanical properties scaffold: compressive strength increased a factor ~7. composite involving Bioglass® particles impart rutile scaffold necessary bioactivity for intended applications in bone tissue engineering. dense hydroxyapatite layer formed on surface foams upon immersion simulated body fluid 1 week.
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S. Petronis, K.-L. Eckert, J. Gold, E. Wintermantel, Microstructuring ceramic scaffolds for hepatocyte cell culture. Journal of Materials Science: Materials in Medicine. ,vol. 12, pp. 523- 528 ,(2001) , 10.1023/A:1011219729687
J. A. Roether, J. E. Gough, A. R. Boccaccini, L. L. Hench, V. Maquet, R. Jérôme, Novel bioresorbable and bioactive composites based on bioactive glass and polylactide foams for bone tissue engineering Journal of Materials Science: Materials in Medicine. ,vol. 13, pp. 1207- 1214 ,(2002) , 10.1023/A:1021166726914
Lorna J. Gibson, Michael F. Ashby, Cellular Solids: Structure and Properties ,(1988)
K. Rezwan, Q.Z. Chen, J.J. Blaker, Aldo Roberto Boccaccini, BIODEGRADABLE AND BIOACTIVE POROUS POLYMER/INORGANIC COMPOSITE SCAFFOLDS FOR BONE TISSUE ENGINEERING Biomaterials. ,vol. 27, pp. 3413- 3431 ,(2006) , 10.1016/J.BIOMATERIALS.2006.01.039
Mika Jokinen, Marko P�tsi, Hanna Rahiala, Timo Peltola, Mikko Ritala, J. B. Rosenholm, Influence of sol and surface properties on in vitro bioactivity of sol‐gel‐derived TiO2 and TiO2‐SiO2 films deposited by dip‐coating method Journal of Biomedical Materials Research. ,vol. 42, pp. 295- 302 ,(1998) , 10.1002/(SICI)1097-4636(199811)42:2<295::AID-JBM15>3.0.CO;2-I
R Nalla, Effect of orientation on the in vitro fracture toughness of dentin: the role of toughening mechanisms. Biomaterials. ,vol. 24, pp. 3955- 3968 ,(2003) , 10.1016/S0142-9612(03)00278-3
Ville V. Meretoja, Teemu Tirri, Virpi Ääritalo, X. Frank Walboomers, John A. Jansen, Timo O. Närhi, Titania and Titania-Silica Coatings for Titanium: Comparison of Ectopic Bone Formation within Cell-Seeded Scaffolds Tissue Engineering. ,vol. 13, pp. 855- 863 ,(2007) , 10.1089/TEN.2006.0234
Qizhi Z. Chen, Ian D. Thompson, Aldo R. Boccaccini, 45S5 Bioglass-derived glass-ceramic scaffolds for bone tissue engineering. Biomaterials. ,vol. 27, pp. 2414- 2425 ,(2006) , 10.1016/J.BIOMATERIALS.2005.11.025
R.K. Nalla, J.H. Kinney, R.O. Ritchie, Mechanistic fracture criteria for the failure of human cortical bone Nature Materials. ,vol. 2, pp. 164- 168 ,(2003) , 10.1038/NMAT832
Anushini I Muthutantri, Jie Huang, Mohan J Edirisinghe, Oana Bretcanu, Aldo R Boccaccini, Dipping and electrospraying for the preparation of hydroxyapatite foams for bone tissue engineering Biomedical Materials. ,vol. 3, pp. 025009- 025009 ,(2008) , 10.1088/1748-6041/3/2/025009