Expression of Human α- and β-Defensins in Odontogenic Keratocysts and Radicular Cysts
作者： Tomohito Yoshimoto , Nobuyoshi Mizukawa , Koichi Sawaki , Makoto Nakano , Eiki Yamachika
DOI: 10.1016/S0915-6992(04)80039-6
关键词: Radicular Cyst 、 Monoclonal antibody 、 Polyclonal antibodies 、 Cytokeratin 、 Enucleation 、 Beta-defensin 2 、 Pathology 、 Immunohistochemistry 、 Lamina propria 、 Biology 、 Surgery 、 Oral surgery 、 Orthopedics and Sports Medicine
摘要: Abstract Objective: To identify the location of human β-defensin-2 and α-defensins in odontogenic keratocysts radicular cysts. Patients Methods: Immunohistochemical staining tissue sections from enucleation specimens 14 patients with 19 cysts, normal oral mucosa 2 healthy volunteers was done using mouse monoclonal antibodies against cytokeratin 5/6 rabbit polyclonal β-defensin-2. Results: Human immunoreactivity evident 10 (72%), 7 cysts (37%). Signals for were detected cytoplasm keratinocytes parakeratinised granular layers both types The localisation Pdefensin-2 did not differ between mucosa. α-defensin but keratinocytes. neutrophils lamina propria. Conclusion: Many generate suggesting that similar defence mechanisms utilising defensins exist as well
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