MULTITRANSMITTER MECHANISMS UNDERLYING SELECTED FUNCTION, PARTICULARLY AGGRESSION, LEARNING AND SEXUAL BEHAVIOR

摘要: Multitransmitter actions of neurotropic drugs are well known at present, e.g. benzodiazepines affect levels and/or turnover GABA, glycine, acetylcholine (ACh), histamine, catecholamines and serotonin (5HT). Less appreciated multitransmitter seemingly specific for single neurotransmitter systems. For instance, changes in ACh induced by DFP catecholamines, 5HT GABA; some these effects reciprocal. Interestingly, besides blocking effect on 5HT, atropine markedly lowers several brain parts absence DFP. Accordingly, when a behavior affects more than one transmitter, primary secondary mechanisms may be involved. behavioral phenomena that should thus analyzed include motor catalepsy (cf. Javoy, this Symposium), chronobiological events, memory learning, hypothalamic behaviors Myers, nociception, aggression, sleep Pujol, Symposium) EEG phenomena, alcohol morphine addiction, sexual excitability. Some will reviewed here. Several types aggression distinguished. Catecholamines, amino acid neurotransmitters involved or more. Cholinomimetics atropinics exert marked both predatory emotional aggression; yet, certain paradigms inducing do not seem to turnover. Neurochemical similarities between aggressive pointed out; furthermore, cases, interplay with hormones. Serotonin, nociception. In DFP-induced analgesia, only but also increased; p-chlorphenylalanine 5,6-dihydroxytryptamine employed conjunction prevent increase levels, increment as analgesia still persist. While experience-specific proteins all learning , cholinergic system particularly important indicated data man. Common denominator many the evoked potential phenomena. Cholinergic act general “desynchronizer”, action being modulated status other neurotransmitters.