Marked, Homogeneous, and Early [18F]Fluorodeoxyglucose–Positron Emission Tomography Responses to Vemurafenib in BRAF-Mutant Advanced Melanoma

Hong Yang, Brian Higgins, Kenneth Kolinsky, Kathryn Packman, Zenaida Go, Raman Iyer, Stanley Kolis, Sylvia Zhao, Richard Lee, Joseph F. Grippo, Kathleen Schostack, Mary Ellen Simcox, David Heimbrook, Gideon Bollag, Fei Su, RG7204 (PLX4032), a Selective BRAFV600E Inhibitor, Displays Potent Antitumor Activity in Preclinical Melanoma Models Cancer Research. ,vol. 70, pp. 5518- 5527 ,(2010) , 10.1158/0008-5472.CAN-10-0646

Gideon Bollag, Peter Hirth, James Tsai, Jiazhong Zhang, Prabha N. Ibrahim, Hanna Cho, Wayne Spevak, Chao Zhang, Ying Zhang, Gaston Habets, Elizabeth A. Burton, Bernice Wong, Garson Tsang, Brian L. West, Ben Powell, Rafe Shellooe, Adhirai Marimuthu, Hoa Nguyen, Kam Y. J. Zhang, Dean R. Artis, Joseph Schlessinger, Fei Su, Brian Higgins, Raman Iyer, Kurt D’Andrea, Astrid Koehler, Michael Stumm, Paul S. Lin, Richard J. Lee, Joseph Grippo, Igor Puzanov, Kevin B. Kim, Antoni Ribas, Grant A. McArthur, Jeffrey A. Sosman, Paul B. Chapman, Keith T. Flaherty, Xiaowei Xu, Katherine L. Nathanson, Keith Nolop, Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF -mutant melanoma Nature. ,vol. 467, pp. 596- 599 ,(2010) , 10.1038/NATURE09454

Rebecca C. Osthus, Hyunsuk Shim, Sunkyu Kim, Qing Li, Rahul Reddy, Mita Mukherjee, Yi Xu, Diane Wonsey, Linda A. Lee, Chi V. Dang, Deregulation of Glucose Transporter 1 and Glycolytic Gene Expression by c-Myc Journal of Biological Chemistry. ,vol. 275, pp. 21797- 21800 ,(2000) , 10.1074/JBC.C000023200

Sarah Everitt, Alan Herschtal, Jason Callahan, Nikki Plumridge, David Ball, Tomas Kron, Michal Schneider-Kolsky, David Binns, Rodney J. Hicks, Michael MacManus, High rates of tumor growth and disease progression detected on serial pretreatment fluorodeoxyglucose-positron emission tomography/computed tomography scans in radical radiotherapy candidates with nonsmall cell lung cancer Cancer. ,vol. 116, pp. 5030- 5037 ,(2010) , 10.1002/CNCR.25392

John A. Curtin, Jane Fridlyand, Toshiro Kageshita, Hetal N. Patel, Klaus J. Busam, Heinz Kutzner, Kwang-Hyun Cho, Setsuya Aiba, Eva-Bettina Bröcker, Philip E. LeBoit, Dan Pinkel, Boris C. Bastian, Distinct Sets of Genetic Alterations in Melanoma The New England Journal of Medicine. ,vol. 353, pp. 2135- 2147 ,(2005) , 10.1056/NEJMOA050092

Ying-Shiun Kao, Jim C. Fong, A novel cross-talk between endothelin-1 and cyclic AMP signaling pathways in the regulation of GLUT1 transcription in 3T3-L1 adipocytes. Cellular Signalling. ,vol. 23, pp. 901- 910 ,(2011) , 10.1016/J.CELLSIG.2011.01.016

Todd D Prickett, , Neena S Agrawal, Xiaomu Wei, Kristin E Yates, Jimmy C Lin, John R Wunderlich, Julia C Cronin, Pedro Cruz, Steven A Rosenberg, Yardena Samuels, Analysis of the Tyrosine Kinome in Melanoma Reveals Recurrent Mutations in ERBB4 Nature Genetics. ,vol. 41, pp. 1127- 1132 ,(2009) , 10.1038/NG.438

Linda Mileshkin, Rodney J. Hicks, Brett G.M. Hughes, Paul L.R. Mitchell, Veena Charu, Barbara J. Gitlitz, David Macfarlane, Benjamin Solomon, Lukas C. Amler, Wei Yu, Andrea Pirzkall, Bernard M. Fine, Changes in 18F-Fluorodeoxyglucose and 18F-Fluorodeoxythymidine Positron Emission Tomography Imaging in Patients with Non–Small Cell Lung Cancer Treated with Erlotinib Clinical Cancer Research. ,vol. 17, pp. 3304- 3315 ,(2011) , 10.1158/1078-0432.CCR-10-2763

Thomas Zander, Matthias Scheffler, Lucia Nogova, Carsten Kobe, Walburga Engel-Riedel, Martin Hellmich, Irini Papachristou, Karin Toepelt, Andreas Draube, Lukas Heukamp, Reinhard Buettner, Yon D. Ko, Roland T. Ullrich, Egbert Smit, Ronald Boellaard, Adriaan A. Lammertsma, Michael Hallek, Andreas H. Jacobs, Andreas Schlesinger, Karin Schulte, Silvia Querings, Erich Stoelben, Bernd Neumaier, Roman K. Thomas, Markus Dietlein, Jürgen Wolf, Early Prediction of Nonprogression in Advanced Non–Small-Cell Lung Cancer Treated With Erlotinib By Using [18F]Fluorodeoxyglucose and [18F]Fluorothymidine Positron Emission Tomography Journal of Clinical Oncology. ,vol. 29, pp. 1701- 1708 ,(2011) , 10.1200/JCO.2010.32.4939

Haesun Choi, Chuslip Charnsangavej, Silvana de Castro Faria, Eric P. Tamm, Robert S. Benjamin, Marcella M. Johnson, Homer A. Macapinlac, Donald A. Podoloff, CT evaluation of the response of gastrointestinal stromal tumors after imatinib mesylate treatment: a quantitative analysis correlated with FDG PET findings. American Journal of Roentgenology. ,vol. 183, pp. 1619- 1628 ,(2004) , 10.2214/AJR.183.6.01831619