Highly multiplexed proteomic platform for biomarker discovery, diagnostics, and therapeutics.

作者: Michael R. Mehan , Rachel Ostroff , Sheri K. Wilcox , Fintan Steele , Daniel Schneider

DOI: 10.1007/978-1-4614-4118-2_20

关键词: Human proteome projectComputational biologyDisease riskDiseaseMedicineProteomics methodsBiomarker discoveryDisease statusProtein expression

摘要: … therapeutics, we describe a novel and versatile high-content proteomics assay that can be used to discover new biomarkers or new targets for therapeutic … diagnostics and therapeutics. …

参考文章(32)
Jürgen Floege, Tammo Ostendorf, Ulf Janssen, Michael Burg, Heinfried H. Radeke, Chandra Vargeese, Stanley C. Gill, Louis S. Green, Nebojsa Janjic, Novel Approach to Specific Growth Factor Inhibition in Vivo : Antagonism of Platelet-Derived Growth Factor in Glomerulonephritis by Aptamers American Journal of Pathology. ,vol. 154, pp. 169- 179 ,(1999) , 10.1016/S0002-9440(10)65263-7
Van Laecke S, Glorieux G, Vanholder R, The middle-molecule hypothesis 30 years after: lost and rediscovered in the universe of uremic toxicity? Journal of Nephrology. ,vol. 21, pp. 146- 160 ,(2008)
Michael R. Mehan, Deborah Ayers, Derek Thirstrup, Wei Xiong, Rachel M. Ostroff, Edward N. Brody, Jeffrey J. Walker, Larry Gold, Thale C. Jarvis, Nebojsa Janjic, Geoffrey S. Baird, Sheri K. Wilcox, Protein signature of lung cancer tissues. PLOS ONE. ,vol. 7, ,(2012) , 10.1371/JOURNAL.PONE.0035157
Jonathan D. Vaught, Chris Bock, Jeff Carter, Tim Fitzwater, Matt Otis, Dan Schneider, Justin Rolando, Sheela Waugh, Sheri K. Wilcox, Bruce E. Eaton, Expanding the Chemistry of DNA for in Vitro Selection Journal of the American Chemical Society. ,vol. 132, pp. 4141- 4151 ,(2010) , 10.1021/JA908035G
Rachel Ostroff, Trudi Foreman, Tracy R. Keeney, Suzanne Stratford, Jeffrey J. Walker, Dom Zichi, The stability of the circulating human proteome to variations in sample collection and handling procedures measured with an aptamer-based proteomics array Journal of Proteomics. ,vol. 73, pp. 649- 666 ,(2010) , 10.1016/J.JPROT.2009.09.004
Manuel Pascual, Gertraud Steiger, Jurek Estreicher, Kevin Macon, John E. Volanakis, Jürg A. Schifferli, Metabolism of complement factor D in renal failure Kidney International. ,vol. 34, pp. 529- 536 ,(1988) , 10.1038/KI.1988.214
Patrick M. M. Bossuyt, The thin line between hope and hype in biomarker research. JAMA. ,vol. 305, pp. 2229- 2230 ,(2011) , 10.1001/JAMA.2011.729
G. KÖHLER, C. MILSTEIN, Continuous cultures of fused cells secreting antibody of predefined specificity Nature. ,vol. 256, pp. 495- 497 ,(1975) , 10.1038/256495A0