An Oskar-Dependent Positive Feedback Loop Maintains the Polarity of the Drosophila Oocyte
作者： Vitaly Zimyanin , Nick Lowe , Daniel St Johnston
DOI: 10.1016/J.CUB.2006.12.044
关键词: Biology 、 Oocyte 、 Drosophila Protein 、 Cytoskeleton 、 Translation (biology) 、 Cell biology 、 Messenger RNA 、 Cell polarity 、 Microtubule 、 oskar
摘要: Summary The localization of oskar mRNA to the posterior Drosophila oocyte defines site assembly the pole plasm, which contains abdominal and germline determinants [1–3]. requires polarization microtubule cytoskeleton, depends on recruitment PAR-1 cortex in response a signal from follicle cells, where it induces an enrichment plus ends [4–7]. Here, we show that overexpressed localizes middle oocyte, as well posterior. This ectopic premature translation Oskar protein, recruits microtubule-plus-end markers center instead pole, indicating regulates polarity cytoskeleton. also plays role normal oocyte; mutants disrupt or strongly reduce ends. Thus, is required stabilize amplify polarity, generating positive feedback loop increase cytoskeleton's polarization, turn directs more mRNA.
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