作者: John C. Ruckdeschel , Herbert K. Oie , Adi F. Gazdar
DOI: 10.1007/978-1-4613-2295-5_3
关键词: In vitro 、 Non small cell 、 Internal medicine 、 Oncology 、 Weight loss 、 Clinical research 、 Lung cancer 、 Chemosensitivity assay 、 Extensive Disease 、 Performance status 、 Medicine
摘要: Clinical research in the past decade has been said to confirm conceptual separation of small cell lung cancer (SCLC) and non-SCLC as distinct clinical entities [1]. As studies have matured, however, a number their findings suggest that boundary may be less clear than originally thought. The ‘responsiveness’ both radiation drugs characterize SCLC yet virtually all patients with extensive disease are dead within 2 years (median survival < 1 year), not dramatically different non-SCLC, most whom one yar about 0.5 year) More important, ability predict which 25% will get response (5% CR, 20% PR) complete therapy is limited global predictors like performance status, prior weight loss extent disease. It wonder investigators feel we reached plateau our treatment using routine cytotoxic therapy.