In Vitro Characterization of Non-Small Cell Lung Cancer

作者: John C. Ruckdeschel , Herbert K. Oie , Adi F. Gazdar

DOI: 10.1007/978-1-4613-2295-5_3

关键词: In vitroNon small cellInternal medicineOncologyWeight lossClinical researchLung cancerChemosensitivity assayExtensive DiseasePerformance statusMedicine

摘要: Clinical research in the past decade has been said to confirm conceptual separation of small cell lung cancer (SCLC) and non-SCLC as distinct clinical entities [1]. As studies have matured, however, a number their findings suggest that boundary may be less clear than originally thought. The ‘responsiveness’ both radiation drugs characterize SCLC yet virtually all patients with extensive disease are dead within 2 years (median survival < 1 year), not dramatically different non-SCLC, most whom one yar about 0.5 year) More important, ability predict which 25% will get response (5% CR, 20% PR) complete therapy is limited global predictors like performance status, prior weight loss extent disease. It wonder investigators feel we reached plateau our treatment using routine cytotoxic therapy.

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