Synthesis of Quinone‐Based N‐Sulfonyl‐1,2,3‐triazoles: Chemical Reactivity of Rh(II) Azavinyl Carbenes and Antitumor Activity
作者： Wagner O. Valença , Thekke V. Baiju , Fernanda G. Brito , Maria H. Araujo , Claudia Pessoa
关键词: Antitumor activity 、 Click chemistry 、 Chemistry 、 Peripheral blood mononuclear cell 、 Cytotoxic T cell 、 Quinone 、 Sulfonyl 、 Stereochemistry 、 Ic50 values 、 Cytotoxicity
摘要: Quinone-based N-sulfonyl-1,2,3-triazoles were synthesized by click chemistry and subsequently evaluated against eight types of cancer cell lines. Some the compounds exhibited potent cytotoxicity with IC50 values < 1.0 μM. Also, cytotoxic potential quinones was peripheral blood mononuclear (PBMC) V79 cells. Additionally, chemical reactivity Rh(II) aza-vinyl carbenes generated in situ from these triazoles studied. These could provide promising new lead derivatives for more anticancer drug development.
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