Trypanosoma cruzi population dynamics in the Central Ecuadorian Coast.

摘要: Chagas disease is the most important parasitic in Latin America. The causative agent, Trypanosoma cruzi, displays high genetic diversity and circulates complex transmission cycles among domestic, peridomestic sylvatic environments. In Ecuador, Rhodnius ecuadoriensis known to be major vector species implicated T. cruzi transmission. However, across vast areas of little about relation different parasite scenarios. Fifty-eight stocks from central Ecuadorian coast, them derived R. ecuadoriensis, were included study. All genotyped as discrete typing unit I (DTU TcI). Analysis 23 polymorphic microsatellite loci through neighbor joining discriminant analysis principal components yielded broadly congruent results indicate subdivision between cycles. both analyses also suggest that any barriers are imperfect significant gene flow subpopulations habitats exists. Also consistent with moderate partition residual subpopulations, fixation index (FST) was significant, but low magnitude. Finally, lack private alleles domestic/peridomestic cycle suggests strains constitute ancestral population. The population coast shows tendency according cycle. connectivity exists harbored by vectors appears a source which invades human domiciles their surroundings this region. We discuss implications these findings have for planning, implementation evaluation local control interventions.