Trypanosoma cruzi: Biological characterization of lineages I and II supports the predominance of lineage I in Colombia.

摘要: The causes of the particular distribution both Trypanosoma cruzi lineages throughout American continent remain unknown. In Colombia, T. I is predominant group in domestic and sylvatic cycles. Here, we present biological characterization parasites belonging to IIb groups. Our results show inability clones infect mammalian cells, produce trypomastigotes replicate Rhodnius prolixus, main vector species this country. Moreover, result was confirmed when other from same genus, such as R. pallescens robustus, were infected with TcIIb clone its parental strain, while infection genera Triatoma Panstrongylus successful. Furthermore, growth kinetics duplication time vitro suggest that high prevalence Colombia more successful interactions between parasite lineage, vector, host species. This type study may help understand factors influencing epidemiological patterns Chagas disease transmission different endemic regions.