Prevention of fatal cardiac arrhythmias by polyunsaturated fatty acids

作者: Jing X Kang , Alexander Leaf

DOI: 10.1093/AJCN/71.1.202S

关键词: Unsaturated fatty acidMyocyteBiologyOuabainEicosapentaenoic acidEndocrinologyAnti-Arrhythmia AgentsPolyunsaturated fatty acidArachidonic acidInternal medicineSudden death

摘要: … the expected fatal arrhythmias, from which they were defibrillated. The free fatty acids were … attribute the effect to the n–3 fatty acids infused. Another set of experiments was performed …

参考文章(31)
D P Cistola, D M Small, J A Hamilton, Carbon 13 NMR studies of saturated fatty acids bound to bovine serum albumin. I. The filling of individual fatty acid binding sites. Journal of Biological Chemistry. ,vol. 262, pp. 10971- 10979 ,(1987) , 10.1016/S0021-9258(18)60913-5
Ram B. Singh, Mohammad A. Niaz, Jagdish P. Sharma, Rakesh Kumar, Vipul Rastogi, M. Moshiri, Randomized, double-blind, placebo-controlled trial of fish oil and mustard oil in patients with suspected acute myocardial infarction: the Indian experiment of infarct survival--4. Cardiovascular Drugs and Therapy. ,vol. 11, pp. 485- 491 ,(1997) , 10.1023/A:1007757724505
J. X. Kang, A. Leaf, Effects of long-chain polyunsaturated fatty acids on the contraction of neonatal rat cardiac myocytes Proceedings of the National Academy of Sciences of the United States of America. ,vol. 91, pp. 9886- 9890 ,(1994) , 10.1073/PNAS.91.21.9886
Y.-F. Xiao, A. M. Gomez, J. P. Morgan, W. J. Lederer, A. Leaf, Suppression of voltage-gated L-type Ca2+ currents by polyunsaturated fatty acids in adult and neonatal rat ventricular myocytes Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 4182- 4187 ,(1997) , 10.1073/PNAS.94.8.4182
V. N. Civelek, J. A. Hamilton, K. Tornheim, K. L. Kelly, B. E. Corkey, Intracellular pH in adipocytes: effects of free fatty acid diffusion across the plasma membrane, lipolytic agonists, and insulin Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 10139- 10144 ,(1996) , 10.1073/PNAS.93.19.10139
M.L. Burr, J.F. Gilbert, R.M. Holliday, P.C. Elwood, A.M. Fehily, S. Rogers, P.M. Sweetnam, N.M. Deadman, EFFECTS OF CHANGES IN FAT, FISH, AND FIBRE INTAKES ON DEATH AND MYOCARDIAL REINFARCTION: DIET AND REINFARCTION TRIAL (DART) The Lancet. ,vol. 334, pp. 757- 761 ,(1989) , 10.1016/S0140-6736(89)90828-3
Peter L. McLennan, Mahinda Y. Abeywardena, John S. Charnock, Dietary fish oil prevents ventricular fibrillation following coronary artery occlusion and reperfusion American Heart Journal. ,vol. 116, pp. 709- 717 ,(1988) , 10.1016/0002-8703(88)90328-6
C D Malis, A Leaf, G S Varadarajan, J B Newell, P C Weber, T Force, J V Bonventre, Effects of dietary omega 3 fatty acids on vascular contractility in preanoxic and postanoxic aortic rings. Circulation. ,vol. 84, pp. 1393- 1401 ,(1991) , 10.1161/01.CIR.84.3.1393
J. X. Kang, Y. F. Xiao, A. Leaf, Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 3997- 4001 ,(1995) , 10.1073/PNAS.92.9.3997