Immunophenotypic differences between normal glia, astrocytomas and malignant gliomas: correlations with karyotype, natural history and survival

作者: Mark T. Jennings , Salah A.D. Ebrahim , H. Tzvi Thaler , V.DeVeta L. Jennings , Laura L.H. Asadourian

DOI: 10.1016/0165-5728(89)90082-9

关键词: AntigenImmunophenotypingKaryotypeCytogeneticsAstrocytomaPhenotypeMonoclonal antibodyPathologyMonoclonalBiology

摘要: Abstract The karyotypic and antigenic phenotypes of early passage normal malignant glial cultures were correlated in vitro. Astrocytomas (4) distinguished from the glia (8) by a mixed near-diploid karyotype anchorage-independent growth. Malignant gliomas (41) demonstrated cytogenetic abnormalities ranging G- Q-banded culture, through near-diploid/hyperdiploid to predominantly hyperdiploid stem-lines. This with differential expression certain antigens established qualitative differences glia.Associations found between histopathologic grade neoplasm 5.1H11 ( p = 0.0002), CNT/11 0.001), CNT/10 0.004), CAT301 0.014), M111 0.024), L101 0.044). An ominous association was duration clinical survival 0.0007), 0.027) B2.6 0.038). Correcting for diagnosis age, multivariate analysis that HLA-DR 0.050) 0.069) unfavorably patient survival. suggests application vitro immunophenotype its predictive utility, as well novel method selection tumor-associated monoclonal antibody-mediated immunotherapy.

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