Defining Y-SNP Variation Among the Flemish Population (Western Europe) by Full Genome Sequencing

摘要: Y-chromosomal single nucleotide polymorphisms (Y-SNPs) represent a powerful tool in forensic research and casework, especially for inferring paternal ancestry of unknown perpetrators unidentified bodies. However, the wealth recently discovered Y-SNPs, 'jungle' different evolutionary lineage trees nomenclatures, lack population-wide data many phylogenetically mapped limits use Y-SNPs routine approaches. Recently, concise reference phylogeny human Y chromosome, 'Minimal Reference Y-tree', was introduced aiming to provide stable with optimal global discrimination capacity by including most resolving Y-SNPs. Here, we obtained representative sample 270 whole-genome sequences (WGS) grasp Y-SNP variation within autochthonous Flemish population (Belgium, Western Europe) according this Y-tree. The high quality calling guaranteed WGS as well its representativeness based on comparison main haplogroup frequencies those from earlier studies Flanders Netherlands. chromosomes were assigned 98 sub-haplogroups Minimal Y-tree, showing potential confirming spectrum lineages Europe general particular. full database all calls is public available future updates genetic studies. New initiatives categorise other populations chromosome are highly encouraged applications. Recommendations realise such sets discussed study.