Nitroaspirin corrects immune dysfunction in tumor-bearing hosts and promotes tumor eradication by cancer vaccination

摘要: Active suppression of tumor-specific T lymphocytes can limit the immune-mediated destruction cancer cells. Of various strategies used by tumors to counteract immune attacks, myeloid suppressors recruited growing cancers are particularly efficient, often resulting in induction systemic lymphocyte dysfunction. We have previously shown that mechanism which cells from tumor-bearing hosts block defense involves two enzymes metabolize l-arginine: arginase and nitric oxide (NO) synthase. NO-releasing aspirin is a classic molecule covalently linked NO donor group. does not possess direct antitumor activity. However, interfering with inhibitory enzymatic activities cells, orally administered normalized status hosts, increased number function tumor-antigen-specific lymphocytes, enhanced preventive therapeutic effectiveness immunity elicited vaccination. Because vaccines currently being investigated independent phase I/II clinical trials, these findings offer rationale combine treatments subjects advanced neoplastic diseases.