Chromosome aberrations and sister-chromatid exchange in workers in chemical laboratories and a rotoprinting factory and in children of women laboratory workers.

作者: F. Funes-Cravioto , B. Kolmodin-Hedman , J. Lindsten , M. Nordenskjöld , C. Zapata-Gayon

DOI: 10.1016/S0140-6736(77)91485-4

关键词: Sister chromatid exchangeChromatidControl subjectsPhysiologyChromosomeBiological significancePregnancyGeneticsMedicine

摘要: Abstract Cultured lymphocytes from 73 workers in chemical laboratories and the printing industry were found to have a significantly increased frequency of chromatid isochromatid breaks, comparison with 49 control subjects (42 adults 7 children). An increase same magnitude was also 14 children, aged 4 days-11 yr, 11 women laboratory who had worked during pregnancy. A significant correlation between age chromosome aberrations noted for both exposed children but not adults. The sister-chromatid exchange 12 technicians working performing hormone analysis. 2 female pregnancy exchange. cause biological significance these findings are yet known.

参考文章(16)
Court Brown, Chromosome studies on adults Published for the Galton Laboratory, University of London, by Cambridge University Press. ,(1966)
D.G. Harnden, I.M. Tough, P.G. Smith, W.M.Court Brown, Chromosome studies on workers exposed to atmospheric benzene European Journal of Cancer (1965). ,vol. 6, pp. 49- 55 ,(1970) , 10.1016/0014-2964(70)90053-8
BO LAMBERT, KERSTIN HANSSON, JAN LINDSTEN, MARGARETA STEN, BARBRO WERELIUS, Bromodeoxyuridine-induced sister chromatid exchanges in human lymphocytes. Hereditas. ,vol. 83, pp. 163- 173 ,(2009) , 10.1111/J.1601-5223.1976.TB01582.X
Francisco Funes-Cravioto, Bo Lambert, Jan Lindsten, Lars Ehrenberg, A.T. Natarajan, Siv Osterman-Golkar, CHROMOSOME ABERRATIONS IN WORKERS EXPOSED TO VINYL CHLORIDE The Lancet. ,vol. 305, pp. 459- ,(1975) , 10.1016/S0140-6736(75)91534-2
Alessandra Forni, Emma Paciftco, Antonio Limonta, Chromosome Studies in Workers Exposed to Benzene or Toluene or Both Archives of Environmental Health. ,vol. 22, pp. 373- 378 ,(1971) , 10.1080/00039896.1971.10665858
Francisco Funes-Cravioto, K.N. Yakovienko, N.P. Kuleshov, V.S. Zhurkov, Localization of chemically induced breaks in chromosomes of human leucocytes. Mutation Research. ,vol. 23, pp. 87- 105 ,(1974) , 10.1016/0027-5107(74)90164-X
M. Bauchinger, E. Schmid, H.J. Einbrodt, J. Dresp, Chromosome aberrations in lymphocytes after occupational exposure to lead and cadmium. Mutation Research\/genetic Toxicology. ,vol. 40, pp. 57- 61 ,(1976) , 10.1016/0165-1218(76)90023-9
I. Szentesi, É. Hornyák, G. Ungváry, A. Czeizel, Z. Bognár, M. Timar, High rate of chromosomal aberration in PVC workers. Mutation Research. ,vol. 37, pp. 313- 316 ,(1976) , 10.1016/0027-5107(76)90045-2