Cytogenetic studies in human sperm.
作者： A.M. Estop , K. Cieply , V. Vankirk , S. Munne , K. Garver
DOI: 10.1007/BF00197166
关键词: Andrology 、 Cytogenetics 、 Chromatid 、 Biology 、 Sperm 、 Chromosome 15 、 Chromosome 、 Chromosomal fragile site 、 Genetics 、 Semen 、 Chromosome Breakpoints
摘要: Sperm chromosome studies were performed in seven males. One of them had a history exposure to lysergic acid (LSD) although he was free the drug for 1 year before study began. Sixteen ejaculates provided total 555 fully analyzable sperm cells. The overall frequency hyperhaploid cells 2% and that structural abnormality 3.6%. most common breaks followed by small fragments unknown origin. Three breakpoints, 10q25, 2q21, 9q21, involved twice different or chromatid type aberrations. Two these, 10q25 correspond chromosomal locations known as fragile sites.
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