In vivo alteration of antibody production in patients with IgA nephropathy.

摘要: Augmentation of IgA production has been postulated for the development nephropathy. An influenza HA vaccine was administered to healthy adults and patients with nephropathy elucidate if there any in vivo alteration antibody response antigenic stimulation these patients. The s.c. a dose 350 CCA units at an interval 4 weeks. IgG, IgM class antibodies antigens three classes rheumatoid factors (RF) were determined using solid phase fluorescence immunoassay. titres IgG did not change significantly either group after vaccination. No significant differences observed between two groups. increased only 4th week continued 8th week. always higher than controls during study period. stepwise both groups equal degree. RF controls. It is concluded that might be high responders production, polyclonal activation associated following