Stimuli-responsive protoporphyrin IX silica-based nanoparticles for photodynamic therapy in vitro

摘要: Nanoparticle-based delivery systems have been explored recently as efficient vehicles to transport photosensitizers for photodynamic therapy (PDT). In this study; we report the synthesis, characterization and in vitro application of a stimuli-responsive silica nanoparticle platform chemically functionalized with protoporphyrin IX (RR–PpIX–SiNPs). PpIX attached surface SiNPs through redox-responsive linker. molecules can be selectively released from RR–PpIX–SiNP their monomeric form presence highly reducing environment found cancer cells. The structural, photophysical photochemical properties RR–PpIX–SiNPs were characterized compared control sample (PpIX–SiNPs), which does not contained Cell viability measurements demonstrated that more phototoxic than PpIX–SiNPs. Confocal microscopy shows are mainly localized lysosomes. Finally, release was solution using UV-vis spectrometry confocal microscopy, respectively. We envision further modification render colloidal stability target-specific by grafting polymeric chains small or biomolecules.