Transforming Growth Factor-β Effects on Meningioma Cell Proliferation and Signal Transduction Pathways

摘要: The role of transforming growth factor-β (TGF-β) in regulation meningioma and intracellular events transducing its signals are not established. In this study, we evaluated the effects TGF-β on basal cell proliferation 10 primary human cultures whether TGF-β's transduced by Smad 2/3, MAPK/Erk kinase-1(MEK-1)-mitogen-activated protein kinase (MAPK), Akt-p70S6K or p38-JUNK pathways 5. We also tested neutralizing antibodies to alter CSF stimulation proliferation. On average, reduced [3H]-thymidine incorporation 58% controls at 24% 61% 36 h. inhibition was associated with a suggestion increased phosphorylation 2/3 2 cases high 3 but no change activation MEK-1-MAPK, pathways. As shown previously, stimulated tested. Neutralizing antibody against augmented cultures. These findings suggest that exerts largely inhibitory effect proliferation, perhaps part through 2/3.