Anxiolytic-like effects of NMDA/glycine-B receptor ligands are abolished during the elevated plus-maze trial 2 in rats
作者： Leandro J. Bertoglio , Antonio P. Carobrez
DOI: 10.1007/S00213-003-1558-Z
关键词: GABAA receptor 、 Glycine receptor 、 Mechanism of action 、 Anxiolytic 、 Elevated plus maze 、 Internal medicine 、 Endocrinology 、 NMDA receptor 、 Chemistry 、 Receptor 、 Pharmacology 、 Glycine
摘要: Rationale Drugs enhancing the GABAA and/or reducing NMDA/glycine-B receptor activity produce an anxiolytic effect. Regarding former drugs (e.g. benzodiazepines), prior elevated plus-maze (EPM) test experience abolishes trial 2 activity, a phenomenon referred to as "one-trial tolerance" (OTT).
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sci-hub.se 参考文章(45)
Ricardo Luiz Nunes-de-Souza, Azair Canto-de-Souza, Robert John Rodgers, Effects of intra-hippocampal infusion of WAY-100635 on plus-maze behavior in mice Brain Research. ,vol. 927, pp. 87- 96 ,(2002) , 10.1016/S0006-8993(01)03335-2
R. H. P. Porter, J. T. Greenamyre, Anatomy and physiology of glutamate in the CNS. Neurology. ,vol. 44, ,(1994)
Luis E. Gonzalez, Sandra E. File, A Five Minute Experience in the Elevated Plus-Maze Alters the State of the Benzodiazepine Receptor in the Dorsal Raphe Nucleus The Journal of Neuroscience. ,vol. 17, pp. 1505- 1511 ,(1997) , 10.1523/JNEUROSCI.17-04-01505.1997
Hugh E. Criswell, David H. Overstreet, Amir H. Rezvani, Kevin B. Johnson, Peter E. Simson, Darin J. Knapp, Sheryl S. Moy, George R. Breese, Effects of ethanol, MK-801, and chlordiazepoxide on locomotor activity in different rat lines: dissociation of locomotor stimulation from ethanol preference. Alcoholism: Clinical and Experimental Research. ,vol. 18, pp. 917- 923 ,(1994) , 10.1111/J.1530-0277.1994.TB00060.X
Jiro Itoh, Toshitaka Nabeshima, Tsutomu Kameyama, Utility of an elevated plus-maze for dissociation of amnesic and behavioral effects of drugs in mice European Journal of Pharmacology. ,vol. 194, pp. 71- 76 ,(1991) , 10.1016/0014-2999(91)90125-A
Leandro J Bertoglio, Antonio P Carobrez, Previous maze experience required to increase open arms avoidance in rats submitted to the elevated plus-maze model of anxiety Behavioural Brain Research. ,vol. 108, pp. 197- 203 ,(2000) , 10.1016/S0166-4328(99)00148-5
Robert W. Dunn, Roy Corbett, Stuart Fielding, Effects of 5-HT1A receptor agonists and NMDA receptor antagonists in the social interaction test and the elevated plus maze. European Journal of Pharmacology. ,vol. 169, pp. 1- 10 ,(1989) , 10.1016/0014-2999(89)90811-X
L.J. Bertoglio, A.P. Carobrez, Prior maze experience required to alter midazolam effects in rats submitted to the elevated plus-maze. Pharmacology, Biochemistry and Behavior. ,vol. 72, pp. 449- 455 ,(2002) , 10.1016/S0091-3057(02)00710-4
Sandra E File, Helio Zangrossi, Milena Viana, Frederico G Graeff, None, Trial 2 in the elevated plus-maze: a different form of fear? Psychopharmacology. ,vol. 111, pp. 491- 494 ,(1993) , 10.1007/BF02253541
Robert W. Dunn, Denise M. Flanagan, Lawrence L. Martin, Lisa L. Kerman, Anne T. Woods, Fernando Camacho, Carole A. Wilmot, Michael L. Cornfeldt, Richard C. Effland, Paul L. Wood, Roy Corbett, Stereoselective R-(+) enantiomer of HA-966 displays anxiolytic effects in rodents European Journal of Pharmacology. ,vol. 214, pp. 207- 214 ,(1992) , 10.1016/0014-2999(92)90120-S