Effect of growth hormone and insulin-like growth factor-I on immunoglobulin production by and growth of human B cells
作者： H Kimata , A Yoshida
DOI: 10.1210/JCEM.78.3.8126135
关键词: Insulin-like growth factor 、 Cytokine 、 Cell growth 、 Biology 、 Growth factor 、 Internal medicine 、 Antibody 、 B cell 、 Endocrinology 、 Immunoglobulin E 、 Somatropin
摘要: The effect of human GH and insulin-like growth factor-I (IGF-I) on immunoglobulin (Ig) production by proliferation B cells was studied in serum- hormone-free medium. enhanced the Ig thymidine uptake lymphoblastoid cell lines, CBL GM-1056. IGF-I, but not IGF-II or insulin, also However, GH-induced enhancement mediated IGF-I inasmuch as blocked anti-GH antibody anti-IGF-I receptor antibody. Conversely, IGF-I-induced either CESS, GM-1500, SKW, GM-3332. Furthermore, IgG1, IgG2, IgG3, IgG4, IgA1 IgA2, IgM tonsillar stimulated with S...
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