Prediction of Ischemic Events after Percutaneous Coronary Intervention: Thrombelastography Profiles and Factor XIIIa Activity
作者： Rolf Kreutz , Glen Schmeisser , Andrea Schaffter , Sri Kanuri , Janelle Owens
关键词: Medicine 、 Internal medicine 、 Conventional PCI 、 Myocardial infarction 、 Thrombelastography 、 Percutaneous coronary intervention 、 Clinical endpoint 、 Fibrin 、 Factor XIII 、 Cardiology 、 Factor XIIIa
摘要: Background High plasma fibrin clot strength (MA) measured by thrombelastography (TEG) is associated with increased risk of cardiac events after percutaneous coronary interventions (PCIs). Factor XIIIa (FXIIIa) cross-links soluble fibrin, shortens formation time (TEG-K), and increases final (MA). Methods We analyzed platelet-poor from patients previous PCI. Kaolin-activated TEG (R, K, MA) in citrate FXIIIa were (n = 257). Combined primary endpoint was defined as recurrent myocardial infarction (MI) or cardiovascular death (CVD). Relationship measurements on explored. Results FXIIIa correlated TEG-MA (p = 0.002) inversely TEG-K (p Conclusion FXIIIa higher low TEG-K. High activity a modest increase PCI, but less sensitive specific than TEG-MA. Addition does not provide additional stratification beyond high phenotype TEG.
thieme-connect.de参考文章(31)
I. KOMÁROMI, Z. BAGOLY, L. MUSZBEK, Factor XIII: novel structural and functional aspects. Journal of Thrombosis and Haemostasis. ,vol. 9, pp. 9- 20 ,(2011) , 10.1111/J.1538-7836.2010.04070.X
Abbas Bitar, Rolf P. Kreutz, Role of Thrombelastography (TEG) in Risk Assessment and Guidance of Antithrombotic Therapy in Patients with Coronary Artery Disease Drug Development Research. ,vol. 74, pp. 533- 540 ,(2013) , 10.1002/DDR.21112
Jerrold H. Levy, Charles Greenberg, Biology of Factor XIII and clinical manifestations of Factor XIII deficiency Transfusion. ,vol. 53, pp. 1120- 1131 ,(2013) , 10.1111/J.1537-2995.2012.03865.X
Paul A. Gurbel, Kevin P. Bliden, Kirk Guyer, Peter W. Cho, Kazi A. Zaman, Rolf P. Kreutz, Ashwani K. Bassi, Udaya S. Tantry, Platelet reactivity in patients and recurrent events post-stenting: results of the PREPARE POST-STENTING Study. Journal of the American College of Cardiology. ,vol. 46, pp. 1820- 1826 ,(2005) , 10.1016/J.JACC.2005.07.041
Christoph J. Schlimp, Cristina Solomon, Marco Ranucci, Gerald Hochleitner, Heinz Redl, Herbert Schöchl, The Effectiveness of Different Functional Fibrinogen Polymerization Assays in Eliminating Platelet Contribution to Clot Strength in Thromboelastometry Anesthesia & Analgesia. ,vol. 118, pp. 269- 276 ,(2014) , 10.1213/ANE.0000000000000058
Vance G. Nielsen, William Q. Gurley, Thomas M. Burch, The impact of factor XIII on coagulation kinetics and clot strength determined by thrombelastography. Anesthesia & Analgesia. ,vol. 99, pp. 120- 123 ,(2004) , 10.1213/01.ANE.0000123012.24871.62
Joanne L. Mitchell, Ausra S. Lionikiene, Steven R. Fraser, Claire S. Whyte, Nuala A. Booth, Nicola J. Mutch, Functional factor XIII-A is exposed on the stimulated platelet surface Blood. ,vol. 124, pp. 3982- 3990 ,(2014) , 10.1182/BLOOD-2014-06-583070
Rolf P. Kreutz, Janelle Owens, Deshun Lu, Perry Nystrom, Yan Jin, Yvonne Kreutz, Zeruesenay Desta, David A. Flockhart, Platelet factor XIIIa release during platelet aggregation and plasma clot strength measured by thrombelastography in patients with coronary artery disease treated with clopidogrel. Platelets. ,vol. 26, pp. 358- 363 ,(2015) , 10.3109/09537104.2014.916793
Paul A Gurbel, Kevin P Bliden, Eli Cohen, Irene A Navickas, Anand Singla, Mark J Antonino, Mulugeta Fissha, Rolf P Kreutz, Ashwani K Bassi, Udaya S Tantry, Race and sex differences in thrombogenicity: risk of ischemic events following coronary stenting. Blood Coagulation & Fibrinolysis. ,vol. 19, pp. 268- 275 ,(2008) , 10.1097/MBC.0B013E3282FF76AE
Deshun Lu, Janelle Owens, Rolf P. Kreutz, Plasma and whole blood clot strength measured by thrombelastography in patients treated with clopidogrel during acute coronary syndromes. Thrombosis Research. ,vol. 132, ,(2013) , 10.1016/J.THROMRES.2013.07.012