Platelet factor XIIIa release during platelet aggregation and plasma clot strength measured by thrombelastography in patients with coronary artery disease treated with clopidogrel.
作者： Rolf P. Kreutz , Janelle Owens , Deshun Lu , Perry Nystrom , Yan Jin
DOI: 10.3109/09537104.2014.916793
关键词:
摘要: AbstractIt has been estimated that up to half of circulating factor XIIIa (FXIIIa) is stored in platelets. The release FXIIIa from platelets upon stimulation with adenosine diphosphate (ADP) patients coronary artery disease treated dual antiplatelet therapy not previously examined. Samples 96 established aspirin and clopidogrel were Platelet aggregation was performed by light transmittance aggregometry platelet-rich plasma (PRP), platelet-poor (PPP) as reference, ADP 5 µM agonist. Kaolin-activated thrombelastography (TEG) citrate PPP. PRP after centrifuged supernatant (PSN) collected. measured PPP PSN. resulted 24% additional PSN compared (99.3 ± 27 vs. 80.3 ± 24%, p < 0.0001). concentration correlated maximal clot strength (...
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