CHORIOCAPILLARIS SIGNAL VOIDS IN MATERNALLY INHERITED DIABETES AND DEAFNESS AND IN PSEUDOXANTHOMA ELASTICUM.

摘要: PURPOSE To evaluate the pattern of choriocapillaris signal voids in maternally inherited diabetes and deafness pseudoxanthoma elasticum eyes before development any geographic atrophy. METHODS The under central macula was imaged with Optovue RTVue XR Avanti using a 10 μm slab thickness. Automatic local thresholding resultant raw data extracted areas absent flow signal, called voids, these were counted logarithmically binned. void patterns analyzed four two patients three elasticum. None had These compared 55 38 healthy control subjects generalized estimating equations. RESULTS images show that model followed power law distribution, but slope offset much lower than normal group, adjusted for age (P < 0.001). disease group more likely to have greater 40,000 μm. CONCLUSION Before overt atrophy, pronounced abnormalities flow. Current clinical measures retinal pigment epithelial health only look cell death, as It is not possible determine from current imaging if loss precedes potential function epithelium, such secretion vascular endothelial growth factor.