Skin Anti-aging Effect of Forsythia viridissima L.Extract
作者： 정택규 , 윤경섭 , 김미진 , 최상원 , 김자영
DOI:
关键词: Forsythia viridissima 、 Reactive oxygen species 、 Human skin 、 Irritation 、 Xanthine oxidase 、 Traditional medicine 、 Botany 、 Xanthine 、 Antioxidant 、 Aging effect 、 Chemistry
摘要: Skin anti-aging effect of Forsythia viridissima L. extract was evaluated by using antioxidant assay, expression type I procollagen, and UVA-induced matrix metalloproteinase-1 in human dermal fibroblasts. Matairesinol-rich showed the scavenging activity radicals reactive oxygen species with IC 50 values 4.50 ㎍/ml against 1,1-diphenyl-2-picrylhydrazly radical 542.43 superoxide xanthine/xanthine oxidase system, respectively. The procollagen increased 33.76% treatment matairesinol-rich extract, MMP-1 reduced 35.78% a dose dependent manner. In skin irritation test, 2% did not show any adverse effect. Also, clinical study indicated that cream group treated 0.2% significantly wrinkles, as compared non-treated (p < 0.05). These results suggest may be useful potential source functional cosmetics.
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