Contemporary clinical management of endometrial cancer.

摘要: Although the contemporary management of endometrial cancer is straightforward in many ways, novel data has emerged over past decade that altered clinical standards care while generating new controversies will require further investigation. Fortunately most cases are diagnosed at early stages, but high-risk histologies and poorly differentiated tumors have high metastatic potential with a significantly worse prognosis. Initial typically requires surgery, role extent lymphadenectomy debated especially well-differentiated tumors. With changes surgical staging, prognosis correlates more closely stage, importance cytology been questioned under evaluation. The roles radiation intermediate-risk patients chemotherapy emerging. therapeutic index brachytherapy needs to be considered, best sequencing combined modalities balance efficacy toxicities. Additionally targeted therapies show promise, studies needed determine appropriate use these agents. Management continue evolve as trials answer unsolved questions.