The Circadian Clock in the Ventromedial Hypothalamus Controls Cyclic Energy Expenditure

摘要: Organismal homeostasis relies on coherent interactions among tissues, specifically between brain-driven functions and peripheral metabolic organs. Hypothalamic circuits compute information to optimize energetic resources, but the role of circadian clock in these pathways remains unclear. We have generated mice with targeted ablation core-clock gene Bmal1 within Sf1-neurons ventromedial hypothalamus (VMH). While this mutation does not affect central suprachiasmatic nucleus (SCN), VMH controls cyclic thermogenesis brown adipose tissue (BAT), a that governs energy balance by dissipating chemical as heat. VMH-driven control is exerted through increased adrenergic signaling sympathetic nervous system, without affecting BAT's endogenous clock. Moreover, we show computes light feeding inputs modulate basal expenditure. Thus, reveal previously unsuspected circuit where an SCN-independent, hypothalamic BAT function, expenditure, thermogenesis.