Upregulation of thromboxane synthase in human colorectal carcinoma and the cancer cell proliferation by thromboxane A2
作者： Hideki Sakai , Tomoyuki Suzuki , Yuji Takahashi , Masashi Ukai , Katsunori Tauchi
DOI: 10.1016/J.FEBSLET.2006.05.007
关键词: Thromboxane-A synthase 、 Thromboxane A2 、 Cell culture 、 Cancer cell 、 Internal medicine 、 Biology 、 Cancer 、 Prostaglandin H2 、 Endocrinology 、 Colorectal cancer 、 Cancer research 、 Downregulation and upregulation
摘要: Tumor growth of colorectal cancers accompanies upregulation cyclooxygenase-2, which catalyzes a conversion step from arachidonic acid to prostaglandin H2 (PGH2). Here, we compared the expression levels thromboxane synthase (TXS), PGH2 A2 (TXA2), between human cancer tissue and its accompanying normal mucosa. It was found that TXS protein consistently upregulated in tissues different patients. also highly expressed colonic cell lines. Depletion by antisense oligonucleotide inhibited proliferation cells. This inhibition rescued direct addition stable analogue TXA2. The present results suggest overexpression subsequent excess production TXA2 cells may be involved tumor colorectum.
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