Plasticity and redundancy among AMA–RON pairs ensure host cell entry of Toxoplasma parasites

摘要: Malaria and toxoplasmosis are infectious diseases caused by the apicomplexan parasites Plasmodium Toxoplasma gondii, respectively. These have developed an invasion mechanism involving formation of a moving junction (MJ) that anchors parasite to host cell forms ring through which penetrates. The composition assembly MJ, in particular presence protein AMA1 its interaction with RON2 at been subject intense controversy. Here, using reverse genetics, we show AMA1, vaccine candidate, interacts maintain MJ structural integrity T. gondii is subsequently required for internalization. Moreover, disruption gene results upregulation homologues cooperate support residual invasion. Our study highlights considerable complexity molecular plasticity architecture MJ.