Advanced glycation end products inhibit de novo protein synthesis and induce TGF-β overexpression in proximal tubular cells

作者: Sho-Ichi Yamagishi , Yosuke Inagaki , Tamami Okamoto , Shinjiro Amano , Kohachiro Koga

DOI: 10.1046/J.1523-1755.2003.00752.X

关键词: Gene expressionGlycationSecretionMessenger RNAMethylglyoxalInternal medicineEnd stage renal diseaseMolecular biologyIntracellularBiologyEndocrinologyDNA synthesisNephrology

摘要: … We have shown previously that OPB-9195, a novel inhibitor of advanced glycation end products (AGE), significantly prevented renal tubular injury and tubulointerstitial fibrosis in …

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