FDG PET imaging of locally advanced gastric carcinomas: correlation with endoscopic and histopathological findings.

摘要: Gastric cancer carries a poor prognosis and is the second most frequent cause of cancer-related death worldwide. In spite clinical importance this tumour entity, only few fluorine-18 fluorodeoxyglucose positron emission tomography (FDG PET) studies have been published on gastric carcinomas. The aim study was to characterise FDG uptake carcinomas by relating it histopathological properties tumours. Within context, we focussed particularly microscopic growth type according Lauren since our preliminary observations indicated low accumulation in non-intestinal compared with intestinal type. Forty patients locally advanced ten control subjects were studied PET (300 MBq i.v., scan: 40 min p.i., one bed position, measured transmission, filtered back-projection). Detectability tumours qualitatively assessed two independent observers. For quantitative analysis regional standardised values (SUV normalised body surface area) using region interest technique. Qualitative analyses performed respect (intestinal vs type). Other characteristics also assessed: mucus content, grading, extension location. 36 survival rates for detectable non-detectable above below median. Only 24 (60%) detected PET. detection rate significantly higher than that (83% 41%, P=0.01). 2/18 contained extracellular or intracellular whereas 17/22 did so (P<0.01). mean SUV different between (6.7±3.4 4.8±2.8, P=0.03), non-mucus-containing mucus-containing (7.2±3.2 3.9±2.1, P<0.01) grade 2 3 (7.4±2.3 5.2±3.3, P=0.02). not (P=0.85). It concluded malignant may show due special characteristics. overall attributable occurrence diffusely growing types. This limit value diagnosis therapy monitoring Furthermore, intensity predictive