Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors

作者: J. R. Pollack , T. Sorlie , C. M. Perou , C. A. Rees , S. S. Jeffrey

DOI: 10.1073/PNAS.162471999

关键词: Microarray analysis techniquesGeneGeneticsAmplicongenomic DNAComparative genomic hybridizationHuman genomeBiologyCopy-number variationGene dosage

摘要: Genomic DNA copy number alterations are key genetic events in the development and progression of human cancers. Here we report a genome-wide microarray comparative genomic …

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