Serum anti‐GQ1b IgG antibodies recognize surface epitopes on Campylobacter jejuni from patients with Miller Fisher syndrome

摘要: Three patients who had diarrhea prior to the development of Miller Fisher syndrome are presented. Campylobacter jejuni was isolated from stool specimens all patients. High titers anti-GQ1b IgG antibodies were demonstrated in serum these by enzyme-linked immunosorbent assay and thin-layer chromatography overlay. In inhibition studies bound specifically whole bacteria syndrome-associated C. strains. The presence binding epitopes on surface not exclusively associated with a specific Penner serotype. It is suggested that formed during initial infection elicits syndrome. cross-reactivity strains supports hypothesis molecular mimicry between neural tissue.