Reversal of shortened platelet survival in rats by the antifibrinolytic agent, epsilon aminocaproic acid.

摘要: Platelet survival in rabbits and rats is shortened by placing indwelling catheters the aorta; this shortening appears to be at least partly related extent of vessel wall injury platelet interaction with repeatedly damaged wall. Treatment rabbit platelets plasmin other proteolytic enzymes vitro shortens their when they are returned circulation. Because may exposed aortic catheters, we examined effect epsilon-aminocaproic acid (EACA) on rats. At a dose 1 g/kg every 4 h, EACA significantly reduced whole blood fibrinolytic activity prolonged catheters. Mean for untreated was 38.6 +/- 1.9 treated EACA, 53.8 3.8 h. Scanning electron microscopy showed that injured these animals mainly covered fibrin, whereas control did not receive surface little fibrin observed. Thus during continuous result from local generation or release sites where (and possibly leukocytes) interact