A novel glucose-6-phosphate dehydrogenase in Plasmodium falciparum
作者： M. Shahabuddin , D.J. Rawlings , D.C. Kaslow
DOI: 10.1016/0167-4781(94)90269-0
关键词: Gene 、 Complementary DNA 、 Peptide sequence 、 Plasmodium falciparum 、 Glucose-6-phosphate dehydrogenase 、 Biology 、 Molecular mass 、 Biochemistry 、 Protein structure 、 Low copy number 、 Molecular biology 、 Biophysics 、 Genetics 、 Structural biology
摘要: The structure of the parasite-encoded G6PD (PfG6PD) may provide clues about relative protection against malaria in humans with glucose-6-phosphate dehydrogenase (G6PD) deficiency. We have cloned Pfg6pd cDNA encoding a predicted 856 amino acid residues polypeptide calculated molecular mass > 94 kDa. sequence is highly homologous to from other organisms. maps as single or low copy number gene chromosome 14. unusually large N-terminus and distance between NADP-binding site G6PD-binding novel for parasite G6PD. differences human proteins could potentially be exploited designing new chemotherapeutic agents.
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