Immunity during pregnancy: lymphocyte subpopulations and mitogen responsiveness.

摘要: Many hypotheses have been proposed to explain the alteration of maternal immune status that allows fetus escape rejection. Published data using monoclonal antibodies stated there are small variable reductions in circulating T-lymphocytes and little or no change helper-to-suppressor ratios. Specific decreased levels helper T-cells claimed by other workers. Our laboratory has previously reported alterations tritiated thymidine uptake (3H-TdR) HLA during pregnancy. The present study evaluates total T-cells, lymphocyte T-cell subsets, ratios B-cells, blast transformation (LBT) throughout These measurements were compared hormonal changes occurring pregnancy determine whether not a significant correlation on response gestation. Data from 100 women revealed subsets after parturition, as measured antibodies. Helper-to-suppressor within normal limits. B-cells showed decrease (P less than 0.001) postpartum period. There was responsiveness mitogenic stimulation phytohemagglutinin-P (PHA-P), concanavalin-A (CON-A), pokeweed mitogen (PWM) first, second third trimesters 0.01). mechanisms fetal protection recognition remain obscure.