Ulipristal Acetate Interferes With Actin Remodeling Induced by 17β-Estradiol and Progesterone in Human Endometrial Stromal Cells.

摘要: Ulipristal acetate (UPA) is a selective progesterone receptor modulator (SPRM) used for emergency contraception and the medical management of symptomatic uterine fibroids (UF). Treatment with UPA turns in amenorrhea UF volume reduction. associated frequent development benign, transitory endometrial changes known as SPRM-associated (PAECs). Why PAECs develop their biological or cellular basis unknown. Sex steroids, including estrogen progesterone, are established modulators actin cytoskeleton various cells, cells. This explains several morphological functional We thus hypothesized that may alter appearance endometrium by interfering actions 17β-estradiol (E2) (P4) on dynamics. isolated cultured human stromal cells (ESC) from biopsies healthy fertile women. E2 P4 stimulated visible rearrangements remodeling toward membrane. Activation through phosphorylation regulatory proteins, Moesin, focal adhesion kinase (FAK), hacked induced P4. Membrane re-localization Paxillin Vinculin were also P4, showing formation complexes. All these inhibited co-treatment UPA, which was otherwise inactive if given alone. The cytoskeletal turned into increased motility ESC, again blocked In conclusion, we find interferes ESC. finding helps understanding mode SPRMs be relevant other potential clinical applications UPA.