Influence of Cancer-Associated Endometrial Stromal Cells on Hormone-Driven Endometrial Tumor Growth.

摘要: Cancer-associated fibroblasts have been shown to inhibit or stimulate tumor growth depending on stage, grade, and type. It remains unclear, however, the effect of endometrial-cancer-associated hormone-driven responses in endometrial cancer. In this study, we investigated normal cancer-associated stromal cells from patients with without cancer response estradiol (E2) progesterone (P4). Compared benign cells, low-grade high-grade exhibited a blunted hormone for proliferation as well IGFBP1 secretion. Additional analysis influence was done by mixing benign, low-grade, tumors, Ishikawa subcutaneous formation. The presence both increased estradiol-driven xenografted compared alone. Low-grade did not significantly hormone-regulated growth. Addition P4 attenuated + but alone cells. Using an angiogenesis focused real-time array TGFA, TGFB2 TGFBR1 VEGFC were identified potential candidates hormone-influenced regulation tumors summary, responded differently vitro treatment Additionally, differentially influenced xenograft vivo disease status