p53 mutation heterogeneity in cancer

摘要: The p53 gene is inactivated in about 50% of human cancers and the protein an essential component cell response induced by genotoxic stresses such as those generated radiotherapy or chemotherapy. It therefore highly likely that these alterations are important tumor resistance to therapy. particular characteristics alterations, 80% which missense mutations leading functionally heterogeneous proteins, make a unique class suppressor genes. A considerable number mutant proteins probably have oncogenic activity per se actively participate transformation. fact apoptotic antiproliferative functions can be dissociated certain mutants also suggests another level complexity relationships between inactivation neoplasia.