Effect of Methionine Diet on Metabolic and Histopathological Changes of Rat Hippocampus.
作者： Maria Kovalska , Petra Hnilicova , Dagmar Kalenska , Barbara Tothova , Marian Adamkov
DOI: 10.3390/IJMS20246234
关键词: Hippocampal formation 、 Hippocampus 、 Immunofluorescence 、 Neurodegeneration 、 Medicine 、 Hyperhomocysteinemia 、 Stroke 、 Methionine 、 Internal medicine 、 Spatial memory 、 Endocrinology
摘要: Hyperhomocysteinemia (hHcy) is regarded as an independent and strong risk factor for cerebrovascular diseases, stroke, dementias. The hippocampus has a crucial role in spatial navigation memory processes being constantly studied neurodegenerative disorders. We used moderate methionine (Met) diet at dose of 2 g/kg animal weight/day duration four weeks to induce mild hHcy adult male Wistar rats. A novel approach been explore the hippocampal metabolic changes using proton magnetic resonance spectroscopy (1H MRS), involving 7T MR scanner combination with histochemical immunofluorescence analysis. found alterations profile, well remarkable histo-morphological such increase volume, number morphology astrocytes, neurons, their selective vulnerable brain area animals treated Met-enriched diet. Results both methodologies suggest that induced by alters pattern, profile area, which might eventually endorse processes.
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