Gamma delta T-cell differentiation and effector function programming, TCR signal strength, when and how much?

摘要: γδ T-cells boast an impressive functional repertoire that can paint them as either champions or villains depending on the environmental and immunological cues. Understanding function of various effector subsets necessitates tracing developmental program these subsets, including point lineage bifurcation from αβ T-cells. Here, we review importance signals T-cell receptor (TCR) in determining versus fate, further discuss how molecular components this pathway may influence programming subsets. Additionally, role temporal windows restricting development IL-17 producing subtypes, explore whether fetal adult hematopoietic progenitors maintain same potential for giving rise to important subset.